At 300 Longwood Avenue, Children’s is adjacent both to its teaching affiliate, Harvard Medical School, and to Dana-Farber Cancer Institute. (Dana-Farber and Children’s jointly operate Dana-Farber/Children’s Hospital Cancer Care, a 60-year-old partnership established to deliver comprehensive care to children with and survivors of all types of childhood cancers.) In 2012, Children’s was ranked by U.S. News & World Report as the nation’s number one pediatric hospital, along with the Children’s Hospital of Philadelphia.
With more than 680,000 square feet (63,000 m2) of state-of-the-art laboratory space, Children’s is home to the world’s largest research enterprise based at a pediatric medical center. Its discoveries have benefited children and adults since 1869. More than 1,100 scientists, including 9 members of the National Academy of Sciences, 13 members of the Institute of Medicine and 15 members of the Howard Hughes Medical Institute, comprise Children’s research community. Children’s current initiatives are supported by a record US $225 million in funding, which includes more federal funding than is awarded to any other pediatric facility.
In the John F. Enders Pediatric Research laboratories, named for the Children’s researcher and Nobel Prize recipient who cultured the polio and measles viruses, hundreds of laboratory researchers and physician investigators search for answers to some of the most perplexing diseases.
In 2003, Children’s dramatically increased its research capacity with the opening of the 295,000-square-foot (27,400 m2) Karp Family Research Laboratories. The Karp family gift is one of many important gifts that support Children’s vital research enterprise.
In an effort to support the research community, Children’s Stem Cell Program investigator George Q. Daley, M.D., Ph.D., has made dozens of iPS lines developed at Boston Children’s Hospital available for use by other scientists through the Harvard Stem Cell Institute. To date, cell lines have been distributed to over 65 laboratories worldwide.
In 2010, a drug that boosts numbers of blood stem cells, originally discovered in zebrafish in the Boston Children’s Hospital laboratory of Leonard I. Zon, M.D., went to clinical trial in patients with leukemia and lymphoma.
Through the years, scientists at Children’s have set the pace in pediatric research, identifying treatments and therapies for many debilitating diseases, including those of adulthood.
Boston Children’s Hospital research articles from Innovation Toronto
- Drug ‘cocktail’ plus gene therapy could restore vision in optic nerve injury – January 17, 2016
- Medical millirobots offer hope for less-invasive surgeries – May 31, 2015
- Researchers Regrow Human Corneas: First Known Tissue Grown from a Human Stem Cell – July 5, 2014
- ‘Heart disease-on-a-chip’
- Potential peanut allergy breakthrough garners Genentech’s interest at Children’s Hospital
- Injectable ‘Smart Sponge’ Holds Promise for Controlled Drug Delivery