Researchers from the Moscow Institute of Physics and Technology (MIPT), the Engelhardt Institute of Molecular Biology (EIMB RAS), the Institute of Bioorganic Chemistry (IBCh) and a number of other Russian research centers have developed a new method of diagnosing colorectal cancer. The results of the study have been published in Cancer Medicine.
The scientists have created a hydrogel-based biochip to help detect bowel cancer i.e. colorectal cancer (CRC). CRC is the third most common type of cancer and it develops with minimal clinical symptoms in the early stages. Despite doctors’ efforts, the 5-year survival rate does not exceed 36%. Treatment is only effective, and patients only have a good chance of recovery, if the cancer is detected early.
Diagnostic methods that are currently in use are not sufficient. Analyses carried out in vitro have low specificity and invasive studies such as colonoscopy are not only traumatic, but they are also not always suitable for an early diagnosis, as they do not give a complete picture of the development and distribution of colorectal cancer.
The method proposed by scientists from EIMB RAS, MIPT, the Russian Scientific Center of Surgery, Sechenov First Moscow State Medical University, the Institute of Bioorganic Chemistry, and Buyanov City Clinical Hospital is based on the simultaneous detection of various substances in patients’ blood. These substances are autoantibodies against tumor-associated glycans, which can be found in serum at the early stages of cancer, immunoglobulins of different classes, and oncomarkers (molecules produced by tumor cells).