Scientists at the Gladstone Institutes have invented a new way to create three-dimensional human heart tissue from stem cells. The tissue can be used to model disease and test drugs, and it opens the door for a precision medicine approach to treating heart disease. Although there are existing techniques to make three-dimensional tissues from heart cells, the new method dramatically reduces the number of cells needed, making it an easier, cheaper, and more efficient system.
“We have bioengineered micro-scale heart tissues with a method that can easily be reproduced, which will enable scientists in stem cell biology and the drug industry to study heart cells in their proper context,” said first author Nathaniel Huebsch, PhD, a postdoctoral fellow in the Conklin lab at Gladstone. “In turn, this will enhance our ability to discover treatments for heart disease.”
Creating heart cells from induced pluripotent stem cells (iPSCs) that are derived from a patient’s skin cells enables scientists to study and test drugs on that patient’s specific disease. However, cells made from iPSCs are relatively immature, resembling heart cells in an embryo more than cells in an adult. As such, these cells are inadequate for drug testing because they do not properly predict how a drug will affect adult heart cells. Additionally, heart cells created from iPSCs are challenging to make and work with, so creating large quantities can be difficult. Therefore, the fewer cells needed, the better.
The micro heart muscle addresses both of these concerns.