Mass-produced microvalves are the key to scalable production of disposable, plug-and-play microfluidic devices
The elusive ‘lab on a chip’ capable of shrinking and integrating operations normally performed in a chemical or medical laboratory on to a single chip smaller than a credit card, may soon be realized thanks to disposable, plug-and-play microfluidic devices developed by A*STAR researchers1.
Microfluidic systems use networks of channels much narrower than a human hair to control the movement of miniscule amounts of fluids. Recent advances in microfluidics technology have proven invaluable for immediate point-of-care diagnosis of diseases and have greatly improved enzymatic and DNA analysis. High throughput microfluidic systems are also being employed in stem cell studies and for the discovery of new drugs.
A stumbling block for successful miniaturization and commercialization of fully integrated microfluidic systems, however, has been the development of reliable microfluidic components, such as microvalves and micropumps. Zhenfeng Wang and colleagues from the Singapore Institute of Manufacturing Technology (SIMTech), A*STAR have removed that obstacle by developing an efficient and scalable method to fabricate disposable plug-and-play microfluidic devices.
“Integrating valves and pumps into thermoplastic devices is usually challenging and costly because the fabrication process is very complicated,” says Wang. “Mass-producing the microvalve module separately from the main device, however, makes the fabrication of the main device relatively simple and robust.”