Scientists at the University of Lincoln, UK, have successfully produced two synthetic derivatives of Teixobactin – the world’s first known antibiotic capable of destroying ‘drug resistant’ bacteria.
Last year, the discovery of the antibiotic Teixobactin by researchers in the USA was hailed as a ‘game-changer’ in the fight against antimicrobial resistance.
Teixobactin, which kills a range of pathogens without detectable resistance, was isolated from microorganisms (which do not grow under laboratory conditions) found in soil – the natural source of nearly all antibiotics developed since the 1940s.
However in order for it to be developed as a potential drug treatment, several versions of the antibiotic must be produced via chemical synthesis in order to overcome the hurdles of drug development. Researchers in laboratories around the world have been working towards this objective since last year’s breakthrough.
Now Dr Ishwar Singh from the University of Lincoln and his colleagues have become the first group of scientists to synthetically produce two derivatives of Teixobactin.