Two patients with melanoma that had spread to the liver survived for at least 8.5 and 12 years after resection of the hepatic tumor and treatment with patient-specific immunotherapeutic vaccines.
The vaccines, designed to activate the immune system against the tumor, were derived from the patients’ own dendritic cells loaded with proteins isolated from their tumors, as described in an article published in Cancer Biotherapy and Radiopharmaceuticals, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers (http://www.liebertpub.com/). The article is available free for download on the Cancer Biotherapy and Radiopharmaceuticals (http://online.liebertpub.com/doi/full/10.1089/cbr.2016.2003) website until June 10, 2016.
Robert O. Dillman, MD, formerly Vice President Oncology, Caladrius Biosciences, Inc. and currently Chief Medical Officer, NeoStem Oncology (Irvine, CA) and Executive Medical and Scientific Director, Hoag Cancer Institute (Newport Beach, CA) discusses the typically poor prognosis for patients with melanoma of the eye or skin that spreads to the liver, and reports on the potential to achieve long-term survival without disease progression in a subset of patients using the eltrapuldencel-T vaccine. One patient had no disease progression for more than 4.5 years, while the other patient survived and remained disease-free for more than 12 years.
Smartphones can already do pretty much everything, right? Actually, UAB computer scientists have a few more ideas.
They’re tapping into the accelerometers, proximity sensors and other environment-aware chips packed into modern phones to help users stay safe — and keep ahead of the bad guys.
Here are seven innovations that could be coming soon to your favorite device.
1. Watching your back
Most of us are very protective of our phones. Ragib Hasan, Ph.D., an assistant professor in the UAB College of Arts and Sciences Department of Computer and Information Sciences and director of SECRETLab, wants them to return the favor. He is developing software to turn a phone into a digital wingman, using information from its camera, microphone, accelerometer and other sensors to gauge a user’s attentiveness and respond appropriately. When it detects that a person is driving, for example, it could silence all but the most important alerts. If it decides from the way that you’re walking and talking that you are drunk, it could prevent you from making bank transactions. Hasan’s code will also save important security warnings for times when you are alert, rather than groggy from sleep.
The project builds on a study by Munirul Haque, Ph.D., who recently completed a postdoctoral fellowship in Hasan’s lab, and collaborators at Marquette University. The researchers found that a phone can do a remarkably good job at sensing mood. They parsed camera images to read facial expressions and accelerometer data to judge energy expenditure (anxious people tend to pace; inactivity is often a signal of depression). Their system was able to recognize six different “affective states”: anger, disgust, fear, happiness, sadness and surprise.
Passwords are a common security measure to protect personal information, but they don’t always prevent hackers from finding a way into devices.
Researchers from the University of Alabama at Birmingham are working to perfect an easy-to-use, secure login protection that eliminates the need to use a password — known as zero-interaction authentication.