As medical professionals search for new ways to personalize diagnosis and treatment of disease, RPB-supported researchers at the University of Iowa have already put into practice what may be the next big step in precision medicine: personalized proteomics.
Proteomics is the large-scale analysis of all the proteins in a cell type, tissue type, or organism. In contrast to genomics, which shows how genetic differences can indicate a person’s potential for developing a disease over a lifetime, proteomics takes a real-time snapshot of a patient’s protein profile during the disease. Doctors can use this information to tailor diagnosis and initiate treatment, sometimes long before a conventional diagnosis even begins to home in on a cause.
“Proteomics allows us to create a precision molecular diagnosis that’s totally personalized for the patient,” says Vinit Mahajan, M.D., Ph.D., UI clinical assistant professor of ophthalmology and visual sciences, and recipient of a 2011 RPB Career Development Award.
Mahajan’s lab recently used proteomics to devise a successful treatment strategy for a patient with uveitis, a potentially blinding eye disease that can have many causes, making it particularly difficult to diagnose and treat effectively. The team’s findings are described in a paper published in the Feb. 11 issue of the journal JAMA Ophthalmology.
Learn more: The Future of Precision Medicine
The University of Iowa (also known as UI, or simply Iowa) is a flagship public research university located in Iowa City, Iowa.
Founded in 1847, Iowa is the oldest university in the state and it is considered a Public Ivy. The university is organized into eleven colleges offering more than 100 areas of study and seven professional degrees.
The Iowa campus spans 1,900 acres centered along the banks of the Iowa River and includes the University of Iowa Hospitals and Clinics, named one of “America’s Best Hospitals” for the 23rd year in a row. The university was the original developer of the Master of Fine Arts degree and it operates the world-renowned Iowa Writers’ Workshop. Iowa has very high research activity, and is a member of several research coalitions, including the American Association of Universities, the Universities Research Association, and the Committee on Institutional Cooperation. The Iowa alumni network exceeds 250,000, and the university budgeted revenues and expenses of $3.167 billion for 2013.
The Latest Updated Research News:
University of Iowa research articles from Innovation Toronto
- CRISPR Used to Repair Blindness-causing Genetic Defect in Patient-derived Stem Cells – Retinitis Pigmentosa – January 29, 2016
- Researchers create vaccine for dust-mite allergies – July 27, 2014
- No-refrigeration, spray vaccine could curb diseases in remote areas
- A bio patch that can regrow bone
- Chemists develop new approaches to understanding disturbing trends near Earth’s surface
- NASA Spacecraft Embarks on Historic Journey Into Interstellar Space
- A promising target to treat asthma
- China’s Tianhe-2 is the new world champ of supercomputing
- Scientists Coax Brain to Regenerate Cells Lost in Huntington’s Disease in Mouse Model
- Researchers Developing 3D Printer, ‘Bio-Ink’ to Create Human Organs
- Water-resistant coating guards limestone from pollution
- Cell-Based Alternative to Animal Testing?
- Geographic Analysis Offers New Insight Into Coral Disease Spread