Scientists at the University of Lincoln, UK, have successfully produced two synthetic derivatives of Teixobactin – the world’s first known antibiotic capable of destroying ‘drug resistant’ bacteria.
Last year, the discovery of the antibiotic Teixobactin by researchers in the USA was hailed as a ‘game-changer’ in the fight against antimicrobial resistance.
Teixobactin, which kills a range of pathogens without detectable resistance, was isolated from microorganisms (which do not grow under laboratory conditions) found in soil – the natural source of nearly all antibiotics developed since the 1940s.
However in order for it to be developed as a potential drug treatment, several versions of the antibiotic must be produced via chemical synthesis in order to overcome the hurdles of drug development. Researchers in laboratories around the world have been working towards this objective since last year’s breakthrough.
Now Dr Ishwar Singh from the University of Lincoln and his colleagues have become the first group of scientists to synthetically produce two derivatives of Teixobactin.
The University of Lincoln is a British university in the city of Lincoln, England.
The university has origins tracing back to 1861, and after gaining university status in 1992, was known as the University of Humberside until 1996 and the University of Lincolnshire and Humberside until 2001, when it adopted its present name.
Lincoln is one of two universities in the city, alongside Bishop Grosseteste University. Lincoln’s main campus is adjacent to Brayford Pool, the site of urban regeneration in the city since the 1990s; further campuses are located in Riseholme and Holbeach.
The Independent described the university as “the best thing to happen to Lincoln since the Romans”. Lincoln has rapidly moved up in the university rankings, having risen 60 places in 4 years. The Sundays Times Newspaper, responsible for The Times ‘Good University Guide’, recently described the university’s progression as ‘The most dramatic transformation of a university in recent times’. In 2012, the university ranked in the top 50 of the Guardian University Guide for the first time.
It is the University of Lincoln’s annual tradition for student graduation ceremonies to take place at the medieval Lincoln Cathedral.
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