With 1,174 faculty members and more than 27,000 students, UMass Amherst is the largest public university in New England.
The university offers bachelor’s degrees, master’s degrees, and doctoral degrees in 88 undergraduate and 72 graduate areas of study, through eight schools and colleges. The main campus is situated north of downtown Amherst. In a 2009 article for MSN.com, Amherst was ranked first in Best College Towns in the United States. In 2012, U.S. News and World Report ranked Amherst amongst the Top 10 Great College Towns in America.
The University of Massachusetts Amherst is categorized as a Research University with Very High research activity by the Carnegie Foundation for the Advancement of Teaching. In 2011, UMass Amherst had research expenditures of $181.3 million. It is also a member of the Five College Consortium.
University of Massachusetts at Amherst research articles from Innovation Toronto
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- A More Efficient, Lightweight and Low-Cost Organic Solar Cell – September 18, 2014
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UMass Amherst study finds impaired behavior in pregnant and lactating mice
In the first study of its kind, environmental health scientist Laura Vandenberg and neuroscientist Mary Catanese at the University of Massachusetts Amherst examined the effects of the compound bisphenol S (BPS) on maternal behavior and related brain regions in mice. They found subtle but striking behavior changes in nesting mothers exposed during pregnancy and lactation and in their daughters exposed in utero.
BPS, found in baby bottles, personal care products and thermal receipts, is a replacement chemical for BPA and was introduced when concern was raised about possible health effects of that plastic compound. Though studies have found human BPS exposure is likely low, it is widespread and has increased over the past 10 years, the authors note. As with BPA, there is evidence that BPS is an endocrine disruptor.
Assistant professor Vandenberg and Catanese, a recent graduate of UMass Amherst’s neuroscience and behavior graduate program, report, “BPS affects maternal behavior as well as maternally relevant neural correlates.” Their results suggest that maternal care of pups, including mothers’ ability to adjust to the needs of their young during early development, was impaired after BPS exposure “with differing effects based on dose, postpartum period and generational timing of exposure.”
They note effects including “a surprising increased incidence of infanticide” in one treated group and poor maternal care, for example. Details appear in the current issue of Endocrinology.
For this work, the researchers divided pregnant mice into three treatment groups and administered no BPS or one of two low doses of BPS throughout pregnancy and lactation. The researchers then monitored nest-building, pup care and other maternal behaviors during the nursing period. Further, two female offspring from each of these litters were mated with unexposed male mice and tested for maternal behavior using the same assays used to test their mothers.
Trained observers recorded each mother’s position on or off the nest, self grooming, eating, drinking, sleeping/resting, nest repair and pup grooming at three separate time points after pups were born. Animals were also evaluated on time to retrieve pups that were moved out of the nest, another measure of maternal care.
Further, the researchers examined effects of BPS exposure in a brain region sensitive to estrogen or estrogen-mimicking chemicals that is also believed to be important in maternal behavior in mice.
The authors found a surprising increased incidence of infanticide among mouse mothers exposed to the lower dose in utero. Vandenberg and Catanese report that “although these same effects were not seen at the higher dose, more than 10 percent of females exposed to 2 microgram BPS/kg/day either killed their pups or provided such poor instrumental maternal care that one or more pups needed to be euthanized. While not statistically significant, the neglect and poor maternal care we observed were striking.”
In addition to the effects on infanticide, they also found BPS-induced effects on important aspects of maternal care in both exposed mothers and their daughters. They report that females exposed to the higher dose of BPS during pregnancy and lactation spent significantly more time on the nest than controls at one observation point, an unexpected finding given that mouse mothers usually spend less time on the nest as pups grow and develop. The researchers suggest that the mother’s BPS exposure “may indicate a lack of adjustment” to the changing needs of her pups.
BPS-exposed mothers also showed significantly shorter latency to retrieve their first pup and significantly shorter latency to retrieve their entire litter on one of the three observation days, which may not represent improved care but instead “may indicate hyperactivity, compulsivity-like behavior, heightened stress response to scattered pups, or a displaced form of retrieval.”
Different effects were seen in maternal behaviors of the exposed daughters. BPS-exposed daughters spent significantly less time on the nest compared to unexposed controls. The authors also add, “Observations suggesting an inability to attend to the changing development and needs of the pups may also be extended to measures of nest building.” In the exposed daughters, BPS treatment increased time spent nest building on one of the observation days, which “may indicate a repetitive or OCD-like behavior.”
Overall, Vandenberg and Catanese write that “uncovering effects of environmental chemicals that might influence proper maternal care have broad social and public health implications” because from an evolutionary perspective, maternal behavior is related to survival of offspring.
Their theoretical work, tested in experiments in a driving simulator, should help to advance the development of safe semi-autonomous systems (SAS) such as self-driving cars. Such systems rely on human supervision and occasional transfer of control between the human and the automated systems, Zilberstein explains. With substantial support from the National Science Foundation and the auto industry, his lab is working on new approaches to SAS that are controlled collaboratively by a person and a machine while each capitalizes on their distinct abilities.
“Self-driving cars are coming,” says Zilberstein, “but the world is fairly chaotic and not many autonomous systems can cope with that yet. My sense is that we’re pretty far from having fully autonomous systems in cars.” This is because artificial intelligence sensing and decision-making techniques are still limited and no matter how much training and design are used, there is no sufficiently accurate model of the real world that allows such systems to operate reliably.
For example, he suggests, “Trains might be next as a candidate for autonomy, but even then, with a downed branch on the track during a storm, a person may be needed to judge how to proceed safely.”
The researcher says the example highlights a significant challenge that SAS research must address, that is, transferring control quickly, safely and smoothly between the system and the person supervising it. Most systems designed to date do not accomplish this. “Paradoxically,” says Zilberstein, “as we introduce more autonomy, people become less engaged with the operation of the system and it becomes harder for them to take over control.” In the paper presented today, to be published in the conference proceedings, the researchers establish precise requirements to assure that controlling entities can act reliably.
Scientists at the University of Massachusetts Amherst report in the current issue of Small that they have genetically designed a new strain of bacteria that spins out extremely thin and highly conductive wires made up solely of non-toxic, natural amino acids.
“We were blown away by this result,” says Lovley. The conductivity of biowire exceeds that of many types of chemically-produced organic nanowires with similar diameters. The extremely thin diameter of 1.5 nanometers (over 60,000 times thinner than a human hair) means that thousands of the wires can easily be packed into a very small space.
Although proteins are usually electrically insulating, hair-like nanoscale filaments (called pili) on the surface of Geobacter bacteria exhibit metallic-like conductivity. To understand why pili are conductive, scientists from the University of Massachusetts at Amherst, Holy Cross, and Brookhaven National Laboratory recently used X-ray diffraction to analyze the structure of the filaments. They found that the electronic arrangement and the small molecular separation distances (~0.3 nanometers) give the pili an electrical conductivity comparable to that of copper.
These findings can provide useful feedback for studies targeting the enhancement of pili’s electrical conductivity through genetic engineering, which subsequently could be used to construct low-cost, non-toxic, nanoscale, biological sources of electricity for light-weight electronics and for bioremediation.